Published 9 May 2022
Last week, a new NMR system arrived at the Analytical Sciences Department of Aspen Oss. NMR stands for Nuclear Magnetic Resonance, which is a powerful technique to qualitatively and/or quantitatively research materials from solvents to APIs.
This latest addition is a low-field NMR with a field strength of 60 MHz. This new NMR enables Aspen API to bring this powerful analytical-technique inside our factories. The system is small enough to fit on a bench-top or inside a fume hood. However, it has very high sensitivity and sufficient resolution for various at-line analyses.
We are very excited about our new NMR system, because it will help our production facilities to further improve their efficiency and reliability with very fast turn-around times for the analyses and a very high accuracy. Additionally, the technique is very operator friendly, which means that QC-technicians or production personnel will be able to generate the data they need, to facilitate smooth production processes and batch releases.
This low-field NMR is a great addition to our existing 500MHz NMR platform. This is the platform that we currently use for batch releases under cGMP and for our support to Aspen API’s R&D activities. On this platform, we have the flexibility of measuring liquid samples, solid state sample and various types of 2D NMR at high resolution and sensitivity. However, the 500MHz NMR platform is immobile, and only highly qualified personnel can handle it. This where the 60 MHz NMR comes in!
